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1

Synthesis and biological activity of novel 1,4-diazepane derivatives as factor Xa inhibitor with potent anticoagulant and antithrombotic activity

Hiroyuki Koshio, Fukushi Hirayama, Tsukasa Ishihara, Yuta Taniuchi, Kazuo Sato, Yumiko Sakai-Moritani, Seiji Kaku, Tomihisa Kawasaki, Yuzo Matsumoto, Shuichi Sakamoto, Shin-ichi Tsukamoto

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 354 KB

english, 2004

2

Corrigendum to “Antimicrobial susceptibility of common pathogens isolated from postoperative intra-abdominal infections in Japan” [J Infect Chemother 24 (2018) 330–340]

Takesue, Yoshio, Kusachi, Shinya, Mikamo, Hiroshige, Sato, Junko, Watanabe, Akira, Kiyota, Hiroshi, Iwata, Satoshi, Kaku, Mitsuo, Hanaki, Hideaki, Sumiyama, Yoshinobu, Kitagawa, Yuko, Nakajima, Kazuhi

Journal:

Journal of Infection and Chemotherapy

Année:

2018

Langue:

english

Fichier:

PDF, 1.25 MB

english, 2018

3

Pharmacodynamics and pharmacokinetics of YM128, a GPIIb/IIIa antagonist prodrug

Ken-ichi Suzuki, Yumiko Moritani, Nami Hisamichi, Masato Ichihara, Seijiro Akamatsu, Hiroshi Arai, Hiroshi Matsushima, Tomoko Nii, Kazuo Sato, Yuta Taniuchi, Takeshi Shigenaga, Seiji Kaku, Tomihisa Ka

Journal:

Drug Development Research

Année:

2002

Langue:

english

Fichier:

PDF, 287 KB

english, 2002

4

Amperometric enzyme immunoassay for urinary human serum albumin using plasma-treated membrane

Shigeki Kaku, Setsuko Nakanishi, Kazuo Horiguchi, Masanori Sato

Journal:

Analytica Chimica Acta

Année:

1993

Langue:

english

Fichier:

PDF, 1.00 MB

english, 1993

5

Amperometric and colorimetric enzyme immunoassay for urinary human serum albumin using a plasma-treated membrane

Shigeki Kaku, Setsuko Nakanishi, Kazuo Horiguchi, Masanori Sato

Journal:

Analytica Chimica Acta

Année:

1993

Langue:

english

Fichier:

PDF, 630 KB

english, 1993

6

Synthesis of water-soluble, branched polysaccharides having d-mannopyranose, d-arabinofuranose, or oligo-d-arabinofuranose side-chains and their antitumor activity

Kei Matsuzaki, Takaya Sato, Koji Enomoto, Iwao Yamamoto, Ryuichi Oshima, Ken-ichi Hatanaka, Toshiyuki Uryu, Hanae Kaku, Yoshiaki Sone, Akira Misaki

Journal:

Carbohydrate Research

Année:

1986

Langue:

english

Fichier:

PDF, 788 KB

english, 1986

7

Orally active factor Xa inhibitor: synthesis and biological activity of masked amidines as prodrugs of novel 1,4-diazepane derivatives

Hiroyuki Koshio, Fukushi Hirayama, Tsukasa Ishihara, Hiroyuki Kaizawa, Takeshi Shigenaga, Yuta Taniuchi, Kazuo Sato, Yumiko Moritani, Yoshiyuki Iwatsuki, Toshio Uemura, Seiji Kaku, Tomihisa Kawasaki,

Journal:

Bioorganic & Medicinal Chemistry

Année:

2004

Langue:

english

Fichier:

PDF, 350 KB

english, 2004

8

Synthesis and biological activity of novel 1,2-disubstituted benzene derivatives as factor Xa inhibitors

Hiroyuki Koshio, Fukushi Hirayama, Tsukasa Ishihara, Ryouta Shiraki, Takeshi Shigenaga, Yuta Taniuchi, Kazuo Sato, Yumiko Moritani, Yoshiyuki Iwatsuki, Seiji Kaku, Naoko Katayama, Tomihisa Kawasaki, Y

Journal:

Bioorganic & Medicinal Chemistry

Année:

2005

Langue:

english

Fichier:

PDF, 602 KB

english, 2005

9

Changes in the medium-range order of zeolite A by mechanical and thermal amorphization

Toru Wakihara, Kaku Sato, Shinji Kohara, Gopinathan Sankar, Junichi Tatami, Katsutoshi Komeya, Takeshi Meguro, Kenneth J.D. MacKenzie

Journal:

Microporous and Mesoporous Materials

Année:

2010

Langue:

english

Fichier:

PDF, 651 KB

english, 2010

10

Uroleuconaphins A1 and B1, two red pigments from the aphid Uroleucon nigrotuberculatum (Olive)

Mitsuyo Horikawa, Toshihiro Hashimoto, Yoshinori Asakawa, Shigeru Takaoka, Masami Tanaka, Hiroto Kaku, Takeshi Nishii, Kentaro Yamaguchi, Hyuma Masu, Masaki Kawase, Shinya Suzuki, Masao Sato, Tetsuto

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 286 KB

english, 2006

11

Structural and morphological studies on Langmuir-Blodgett films of pheophytine a by ultraviolet–visible and infrared spectroscopies and atomic force microscopy

Hidetoshi Sato, Yushi Oishi, Miyuki Kuramori, Kazuaki Suehiro, Kaku Uehara, Keiji Iriyama, Yukihiro Ozaki

Journal:

Thin Solid Films

Année:

1997

Langue:

english

Fichier:

PDF, 236 KB

english, 1997

12

Design, synthesis and biological activity of YM-60828 derivatives. Part 2: potent and orally-bioavailable factor Xa inhibitors based on benzothiadiazine-4-one template

Fukushi Hirayama, Hiroyuki Koshio, Naoko Katayama, Tsukasa Ishihara, Hiroyuki Kaizawa, Yuta Taniuchi, Kazuo Sato, Yumiko Sakai-Moritani, Seiji Kaku, Hiroyuki Kurihara, Tomihisa Kawasaki, Yuzo Matsumot

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 546 KB

english, 2003

13

A novel mutation in the ferrochelatase gene associated with erythropoietic protoporphyria

S. Imoto, Y. Tanizawa, Y. Sato, K. Kaku, Y. Oka

Journal:

British Journal of Haematology

Année:

1996

Langue:

english

Fichier:

PDF, 447 KB

english, 1996

14

Evaluation of hematuria using the urinary albumin-to-total-protein ratio to differentiate glomerular and nonglomerular bleeding

Noriko Ohisa, Keiji Kanemitsu, Ryouko Matsuki, Hiromi Suzuki, Hideto Miura, Yoshiharu Ohisa, Katsumi Yoshida, Mitsuo Kaku, Hiroshi Sato

Journal:

Clinical and Experimental Nephrology

Année:

2007

Langue:

english

Fichier:

PDF, 242 KB

english, 2007

15

Effects ofAcanthopanax senticosusHARMS extract on drug transport in human intestinal cell line Caco-2

Tsunehisa Takahashi, Tomomi Kaku, Takashi Sato, Kazuhiro Watanabe, Juichi Sato

Journal:

Journal of Natural Medicines

Année:

2010

Langue:

english

Fichier:

PDF, 275 KB

english, 2010

16

Electrophoretic determination of fructose 6-phosphate,2-kinase

Yukari Kora-Miura, Shinya Fujii, Masafumi Matsuda, Yutaka Sato, Kohei Kaku, Toshio Kaneko

Journal:

Analytical Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 702 KB

english, 1988

17

Novel DNA/Polymer conjugate for intelligent antisense reagent with improved nuclease resistance

Masaharu Murata, Wataru Kaku, Takahisa Anada, Yoshikuni Sato, Takeshi Kano, Mizuo Maeda, Yoshiki Katayama

Journal:

Bioorganic & Medicinal Chemistry Letters

Année:

2003

Langue:

english

Fichier:

PDF, 206 KB

english, 2003

18

Quasi-point incoherent ArF∗excimer emission source at 193 nm using a laser-produced plasma

M. Kaku, Y. Sato, S. Kubodera

Journal:

Applied Physics B: Lasers and Optics

Année:

2012

Langue:

english

Fichier:

PDF, 433 KB

english, 2012

19

Biochemical and pharmacological profile of darexaban, an oral direct factor Xa inhibitor

Yoshiyuki Iwatsuki, Takayuki Sato, Yumiko Moritani, Takeshi Shigenaga, Mami Suzuki, Tomihisa Kawasaki, Toshiyuki Funatsu, Seiji Kaku

Journal:

European Journal of Pharmacology

Année:

2011

Langue:

english

Fichier:

PDF, 505 KB

english, 2011

20

Pharmacological properties of YM-57029, a novel platelet glycoprotein IIb/IIIa antagonist

Yumiko Moritani, Kazuo Sato, Takeshi Shigenaga, Nami Hisamichi, Masato Ichihara, Seijiro Akamatsu, Ken-ichi Suzuki, Tomoko Nii, Seiji Kaku, Tomihisa Kawasaki, Yuzo Matsumoto, Osamu Inagaki, Kenichi To

Journal:

European Journal of Pharmacology

Année:

2002

Langue:

english

Fichier:

PDF, 237 KB

english, 2002

21

Antithrombotic effect of YM-75466 is separated from its effect on bleeding time and coagulation time

Kazuo Sato, Seiji Kaku, Fukushi Hirayama, Hiroyuki Koshio, Yuzo Matsumoto, Tomihisa Kawasaki, Yuichi Iizumi

Journal:

European Journal of Pharmacology

Année:

1998

Langue:

english

Fichier:

PDF, 193 KB

english, 1998

22

A Comparison of Urinary Albumin–Total Protein Ratio to Phase-Contrast Microscopic Examination of Urine Sediment for Differentiating Glomerular and Nonglomerular Bleeding

Noriko Ohisa, Katsumi Yoshida, Ryoko Matsuki, Hiromi Suzuki, Hideto Miura, Yoshiharu Ohisa, Nobuki Murayama, Mitsuo Kaku, Hiroshi Sato

Journal:

American Journal of Kidney Diseases

Année:

2008

Langue:

english

Fichier:

PDF, 249 KB

english, 2008

23

NEAR-INFRARED-FT-RAMAN STUDY OF AGGREGATION OF BACTERIOCHLOROPHYLL c IN WHOLE LIVING Chlorobium limicola

Hidetoshi Sato, Kaku Uehara, Takasada Ishii, Yukihiro Ozaki

Journal:

Photochemistry and Photobiology

Année:

1995

Langue:

english

Fichier:

PDF, 490 KB

english, 1995

24

Synergistic effect of aurintricarboxylic acid and triflavin in a photochemically induced thrombosis model in rats

Nami Hisamichi, Tomihisa Kawasaki, Ken-ichi Suzuki, Seiji Kaku, Yumiko Sakai, Yuta Taniuchi, Kazuo Sato, Osamu Inagaki, Kenichi Tomioka, Isao Yanagisawa, Toichi Takenaka, Kennichi Yanagi, Norio Ohshim

Journal:

European Journal of Pharmacology

Année:

1996

Langue:

english

Fichier:

PDF, 484 KB

english, 1996

25

Biochemical characterization of a new disintegrin, flavostatin, isolated from Trimeresurus flavoviridis venom

T. Kawasaki, Y. Sakai, Y. Taniuchi, K. Sato, K. Maruyama, M. Shimizu, S. Kaku, S. Yano, O. Inagaki, K. Tomioka, I. Yanigasawa, T. Takenaka

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 1.07 MB

english, 1996

26

Enhanced Perigraft Angiogenesis Prevents Prosthetic Graft Infection

Shinichi Sato, Yoshio Nitta, Yoshikatsu Saiki, Shunsuke Kawamoto, Atsushi Iguchi, Mitsuo Kaku, Yasuhiko Tabata, Koichi Tabayashi

Journal:

The Annals of Thoracic Surgery

Année:

2008

Langue:

english

Fichier:

PDF, 943 KB

english, 2008

27

Distinct pharmacodynamics of insulin glargine and insulin detemir: Crossover comparison in Type 1 and Type 2 diabetic patients on basal-bolus regimen

Tomoko Kato, Ichiro Tokubuchi, Kazuhisa Muraishi, Shuichi Sato, Tamotsu Kato, Kento Hara, Kayo Tanaka, Hiroo Kaku, Yuji Tajiri, Kentaro Yamada

Journal:

Diabetes Research and Clinical Practice

Année:

2010

Langue:

english

Fichier:

PDF, 164 KB

english, 2010

28

Conservative therapy for adenocarcinoma and atypical endometrial hyperplasia of the endometrium in young women: central pathologic review and treatment outcome

Tsunehisa Kaku, Hiroyuki Yoshikawa, Hitoshi Tsuda, Atsuhiko Sakamoto, Masaharu Fukunaga, Yoshinori Kuwabara, Masaki Hataeg, Shoji Kodama, Kazuo Kuzuya, Shinji Sato, Toshinobu Nishimura, Masamichi Hiur

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 100 KB

english, 2001

29

Effect of Cholecystokinin and Secretin on Colonic Motility and Symptoms in Children with Abdominal Pain

Kenshi Furusho, Kiho Muraishi, Shogo Yoshida, Shozo Kaku, Katsuko Sato, Toshimichi Ohba

Journal:

Pediatrics International

Année:

1977

Langue:

english

Fichier:

PDF, 73 KB

english, 1977

30

Effect of mirabegron, a novel β3-adrenoceptor agonist, on bladder function during storage phase in rats

Toshiki Hatanaka, Masashi Ukai, Mai Watanabe, Akiyoshi Someya, Akiyoshi Ohtake, Masanori Suzuki, Koji Ueshima, Shuichi Sato, Seiji Kaku

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Année:

2013

Langue:

english

Fichier:

PDF, 318 KB

english, 2013

31

First detection of the plasmid-mediated quinolone resistance determinant qnrA in Enterobacteriaceae clinical isolates in Japan

Tomoo Saga, Takaaki Akasaka, Hiroyuki Takase, Mayumi Tanaka, Kenichi Sato, Mitsuo Kaku

Journal:

International Journal of Antimicrobial Agents

Année:

2007

Langue:

english

Fichier:

PDF, 85 KB

english, 2007

32

Comparison of the antiplatelet effect of YM337 and abciximab in rhesus monkeys

Ken-ichi Suzuki, Yumiko Sakai, Nami Hisamichi, Yuta Taniuchi, Kazuo Sato, Chinami Terazaki, Seiji Kaku, Tomihisa Kawasaki, Shinya Yano, Osamu Inagaki, Yasuhiko Masuho

Journal:

European Journal of Pharmacology

Année:

1997

Langue:

english

Fichier:

PDF, 145 KB

english, 1997

33

Top-Down Tuning of Nanosized ZSM-5 Zeolite Catalyst by Bead Milling and Recrystallization

Wakihara, Toru, Ihara, Akio, Inagaki, Satoshi, Tatami, Junichi, Sato, Kaku, Komeya, Katsutoshi, Meguro, Takeshi, Kubota, Yoshihiro, Nakahira, Atsushi

Journal:

Crystal Growth & Design

Année:

2011

Langue:

english

Fichier:

PDF, 2.56 MB

english, 2011

34

A randomized crossover study of the efficacy and safety of switching from insulin glargine to insulin degludec among patients with type 1 diabetes

Yamada, Kentaro, Nakayama, Hitomi, Sato, Shuichi, Tajiri, Yuji, Kaku, Hiroh, Tokubuchi, Ichiro, Kato, Tamotsu, Soejima, Eri, Ohki, Tsuyoshi

Journal:

Diabetology International

Année:

2014

Langue:

english

Fichier:

PDF, 257 KB

english, 2014

35

Detection ofLegionella pneumophilaserogroup 1 in blood cultures from a patient treated with tumor necrosis factor-alpha inhibitor

Kaku, Norihito, Sato, Tsuyoshi, Nakashima, Munetoshi, Nagashima, Seiji, Fukuda, Minoru, Hashiguchi, Kohji, Kaku, Norihito, Yanagihara, Katsunori, Morinaga, Yoshitomo, Yanagihara, Katsunori, Morinaga,

Journal:

Journal of Infection and Chemotherapy

Année:

2013

Langue:

english

Fichier:

PDF, 356 KB

english, 2013

36

Prevalence and clinical features of lymphedema in patients with lymphangioleiomyomatosis

Hoshika, Yoshito, Hamamoto, Takako, Sato, Kayoko, Eto, Hikaru, Kuriyama, Sachiko, Yoshimi, Kaku, Iwakami, Shin-ichiro, Takahashi, Kazuhisa, Seyama, Kuniaki

Journal:

Respiratory Medicine

Année:

2013

Langue:

english

Fichier:

PDF, 934 KB

english, 2013

37

WRKY76 is a rice transcriptional repressor playing opposite roles in blast disease resistance and cold stress tolerance

Yokotani, N., Sato, Y., Tanabe, S., Chujo, T., Shimizu, T., Okada, K., Yamane, H., Shimono, M., Sugano, S., Takatsuji, H., Kaku, H., Minami, E., Nishizawa, Y.

Journal:

Journal of Experimental Botany

Année:

2013

Langue:

english

Fichier:

PDF, 4.54 MB

english, 2013

38

Impact of PNPLA3 polymorphisms on the development of hepatocellular carcinoma in patients with chronic hepatitis C virus infection

Sato, Masaya, Kato, Naoya, Tateishi, Ryosuke, Muroyama, Ryosuke, Kowatari, Norie, Li, Wenwen, Goto, Kaku, Otsuka, Motoyuki, Shiina, Shuichiro, Yoshida, Haruhiko, Omata, Masao, Koike, Kazuhiko

Journal:

Hepatology Research

Année:

2014

Langue:

english

Fichier:

PDF, 622 KB

english, 2014

39

TUBERCULOSIS OF THE URETHRA.

Sato, Noriyuki, Kaku, Toru, Dempo, Kimimaro, Kikuchi, Kokichi

Journal:

Année:

1903

Langue:

english

Fichier:

PDF, 356 KB

english, 1903

40

The relationship of colonic carcinogenesis and hepatic vascular tumors induced by subcutaneously injected-1,2-dimethylhydrazine dihydrochloride in specific pathogen free mice

Sato, Noriyuki, Kaku, Toru, Dempo, Kimimaro, Kikuchi, Kokichi

Journal:

Année:

1984

Langue:

english

Fichier:

PDF, 1.60 MB

english, 1984

41

Speed-of-Sound Measurements Using Spherical Resonator and Acoustic Virial Coefficients for Gaseous Pentafluoroethane (R125)

Kojima, Takeshi, Okabe, Kaku, Ogawa, Kazuhiro, Sato, Haruki

Journal:

Journal of Chemical & Engineering Data

Année:

2004

Langue:

english

Fichier:

PDF, 64 KB

english, 2004

42

Control of Molecular Arrangement in Langmuir−Blodgett Films of Chlorophyll a Prepared in Various Gas Phases Studied by Ultraviolet−Visible and Infrared Spectroscopies and Atomic Force Microscopy †,‡

Sato, Hidetoshi, Ozaki, Yukihiro, Oishi, Yushi, Kuramori, Miyuki, Suehiro, Kazuaki, Nakashima, Kenichi, Uehara, Kaku, Iriyama, Keiji

Journal:

Année:

1997

Langue:

english

Fichier:

PDF, 344 KB

english, 1997

43

Characterization of Amorphized Zeolite A by Combining High-Energy X-ray Diffraction and High-Resolution Transmission Electron Microscopy

Sato, Kaku, Wakihara, Toru, Kohara, Shinji, Ohara, Koji, Tatami, Junichi, Endo, Akira, Inagaki, Satoshi, Kawamura, Izuru, Naito, Akira, Kubota, Yoshihiro

Journal:

The Journal of Physical Chemistry C

Année:

2012

Langue:

english

Fichier:

PDF, 1.86 MB

english, 2012

44

FT-IR and near-infrared FT-Raman study of aggregation of bacteriochlorophyll c in solutions: evidence for involvement of the ester group in the aggregation

Sato, Hidetoshi, Uehara, Kaku, Ishii, Takasada, Ozaki, Yukihiro

Journal:

Année:

1995

Langue:

english

Fichier:

PDF, 732 KB

english, 1995

45

Viridaphin A 1 Glucoside, a Green Pigment Possessing Cytotoxic and Antibacterial Activity from the Aphid Megoura crassicauda

Horikawa, Mitsuyo, Hoshiyama, To-sho, Matsuzawa, Masako, Shugyo, Takanori, Tanaka, Masami, Suzuki, Shinya, Sato, Masao, Ito, Takuya, Asakawa, Yoshinori, Kaku, Hiroto, Nishii, Takeshi, Inai, Makoto, Ta

Journal:

Journal of Natural Products

Année:

2011

Langue:

english

Fichier:

PDF, 1.80 MB

english, 2011

46

Morphology and molecular orientation and structure of Langmuir–Blodgett films of chlorophyll a studied by atomic force microscopy and UV–VIS and IR spectroscopies

Sato, Hidetoshi, Oishi, Yushi, Kuramori, Miyuki, Suehiro, Kazuaki, Kobayashi, Masami, Uehara, Kaku, Araki, Toshinari, Iriyama, Keiji, Ozaki, Yukihiro

Journal:

Journal of the Chemical Society Faraday Transactions

Année:

1997

Langue:

english

Fichier:

PDF, 620 KB

english, 1997

47

[IEEE 2007 Conference on Lasers and Electro-Optics - Pacific Rim - Seoul, South Korea (2007.08.26-2007.08.31)] 2007 Conference on Lasers and Electro-Optics - Pacific Rim - Debris characteristics of a laser-produced plasma extreme ultraviolet emission source using a colloidal tin dioxide nano-particle jet target

Kaku, Masanori, Suetake, Sumiyoshi, Senba, Yusuke, Sato, Yusuke, Katto, Masahito, Kubodera, Shoichi

Année:

2007

Langue:

english

Fichier:

PDF, 128 KB

english, 2007

48

Vibrio parahaemolyticus Chromosomal qnr Homologue VPA0095: Demonstration by Transformation with a Mutated Gene of Its Potential To Reduce Quinolone Susceptibility in Escherichia coli

Saga, T., Kaku, M., Onodera, Y., Yamachika, S., Sato, K., Takase, H.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2005

Langue:

english

Fichier:

PDF, 40 KB

english, 2005

49

Pharmacokinetic-Pharmacodynamic Relationship of Arbekacin for Treatment of Patients Infected with Methicillin-Resistant Staphylococcus aureus

Sato, R., Tanigawara, Y., Kaku, M., Aikawa, N., Shimizu, K.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2006

Langue:

english

Fichier:

PDF, 110 KB

english, 2006

50

Population Pharmacokinetics of Arbekacin in Patients Infected with Methicillin-Resistant Staphylococcus aureus

Tanigawara, Y., Sato, R., Morita, K., Kaku, M., Aikawa, N., Shimizu, K.

Journal:

Antimicrobial Agents and Chemotherapy

Année:

2006

Langue:

english

Fichier:

PDF, 156 KB

english, 2006